Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27743150 | 0.82 | HPGD (0.62) | HPGDLMNAARHTTSMN1; SMN2 | |
| SCHEMBL9568488 | 0.78 | HPGD (0.54) | HPGDLMNAARHTTSMN1; SMN2 | |
| SCHEMBL3255942 | 0.77 | HPGD (0.55) | HPGDLMNAARHTTSMN1; SMN2 | |
| SCHEMBL11346287 | 0.77 | HPGD (0.53) | HPGDLMNAARHTTSMN1; SMN2 | |
| SCHEMBL3805817 | 0.76 | KMT2A (0.68) | HPGDLMNAHTTSMN1; SMN2OPRK1 | |
| SCHEMBL16691162 | 0.74 | CA1 (0.63) | HPGDLMNAARHTTSMN1; SMN2 | |
| SCHEMBL29064938 | 0.73 | KMT2A (0.47) | LMNAHTTMAPTHSD17B10ALDH1A1 | |
| SCHEMBL14416710 | 0.73 | RAB9A (0.50) | LMNAHTTSMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL6984005 | 0.73 | PSIP1 (0.47) | HPGDLMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL29209190 | 0.72 | HPGD (0.54) | HPGDLMNAARHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289950-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096296-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |