Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984795 | 0.84 | PIM1 (0.55) | POLBLMNAKDM4EMAPTHPGD | |
| SCHEMBL7410741 | 0.81 | AKR1B1 (0.47) | LMNAKDM4EMAPTHPGDKMT2A | |
| SCHEMBL3618447 | 0.79 | MAOB (0.62) | KDM4EMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL1968491 | 0.79 | KMT2A (0.55) | LMNAKDM4EMAPTHPGDKMT2A | |
| SCHEMBL18703879 | 0.78 | MAOB (0.52) | LMNAKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL20759007 | 0.78 | KMT2A (0.50) | POLBLMNAKDM4EMAPTHPGD | |
| SCHEMBL2082963 | 0.76 | SLC16A3 (0.59) | POLBLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL6985338 | 0.76 | AKR1B1 (0.66) | LMNAKDM4EMAPTHPGDKMT2A | |
| SCHEMBL23397123 | 0.75 | P4HTM (0.52) | POLBLMNAKDM4EMAPTKMT2A | |
| SCHEMBL8717367 | 0.75 | KMT2A (0.55) | LMNAKDM4EMAPTHPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |