Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717367 | 0.89 | KMT2A (0.55) | AKR1B1MAPTHTTLMNAKMT2A | |
| SCHEMBL6981476 | 0.87 | MAPT (0.50) | AKR1B1MAPTHTTLMNAKMT2A | |
| SCHEMBL6622934 | 0.85 | MAPT (0.53) | AKR1B1MAPTHTTLMNAKMT2A | |
| SCHEMBL8712740 | 0.83 | KMT2A (0.54) | AKR1B1MAPTHTTLMNAKMT2A | |
| SCHEMBL6983542 | 0.82 | PIM1 (0.55) | SLC7A5LMNAKMT2ATSHRALDH1A1 | |
| SCHEMBL6984136 | 0.81 | POLB (0.51) | AKR1B1MAPTHTTLMNAKMT2A | |
| SCHEMBL6985338 | 0.80 | AKR1B1 (0.66) | AKR1B1MAPTHTTLMNAKMT2A | |
| SCHEMBL24848155 | 0.79 | KMT2A (0.69) | MAPTSLC7A5LMNAKMT2ASLC6A2 | |
| SCHEMBL6487713 | 0.78 | GPR119 (0.41) | MAPTGPR119LMNAKMT2ASLC6A2 | |
| SCHEMBL21187892 | 0.78 | MAPT (0.68) | AKR1B1MAPTHTTKMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079821-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | claimed |
| EP-1079821-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999059570-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | claimed |
| EP-1079821-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1079821-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059570-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |