Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 12/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.34 |
| ▸ | PRKACG | P22612 | 2/20 | 0.34 |
| ▸ | PRKACB | P22694 | 2/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980982 | 0.93 | PRKACA (0.39) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.87 | TPSAB1 (0.41) | TPSAB1CAMK2DCA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6986094 | 0.87 | PRKACA (0.45) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL7006503 | 0.87 | TPSAB1 (0.43) | TPSAB1PRKACAPRKACGPRKACBCAMK2D | |
| Trifluoroacetic Acid SCHEMBL6985276 | 0.86 | CAMK2D (0.49) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6984540 | 0.86 | CAMK2D (0.46) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6986763 | 0.82 | TPSAB1 (0.38) | TPSAB1CAMK2DCCNT1CDK9MEN1 | |
| Trifluoroacetic Acid SCHEMBL6982571 | 0.81 | CCNT1 (0.44) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6984632 | 0.80 | PRKCB (0.46) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL6974638 | 0.80 | PRKCB (0.40) | CAMK2DCCNT1CDK9MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |