Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18930268 | 0.77 | LMNA (0.44) | ALDH1A1GAAHTTALOX12HIF1A | |
| SCHEMBL24938982 | 0.75 | MAPT (0.37) | ALDH1A1GAAHTTALOX12HIF1A | |
| SCHEMBL7687653 | 0.75 | P2RX4 (0.39) | CRHR1GAALMNAHPGDKMT2A | |
| SCHEMBL20046659 | 0.75 | POLB (0.35) | ALDH1A1GAAHTTTSHRCYP3A4 | |
| SCHEMBL23773269 | 0.73 | CRHR1 (0.46) | CRHR1ALDH1A1GAAHTTALOX12 | |
| SCHEMBL22751309 | 0.71 | CASR (0.36) | ALDH1A1GAAHTTALOX12HIF1A | |
| SCHEMBL11149004 | 0.71 | ADRA1D (0.49) | ALDH1A1GAAADRA2AADRA2BADRA2C | |
| SCHEMBL18503026 | 0.71 | PDE3B (0.42) | CRHR1ALDH1A1LMNA | |
| SCHEMBL12593462 | 0.70 | LMNA (0.54) | CRHR1ALDH1A1GAAHTTALOX12 | |
| SCHEMBL9909702 | 0.70 | CRHR1 (0.42) | CRHR1ALDH1A1GAAHTTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976745-B1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6187781-B1 | CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0976745-A1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-02 | — | — | EP | disclosed |