Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6987520 | 0.99 | ADAM17 (0.36) | ADAM17MASP2 | |
| SCHEMBL6982898 | 0.90 | GHSR (0.31) | — | |
| SCHEMBL7808298 | 0.87 | TGFBR1 (0.32) | — | |
| SCHEMBL6984051 | 0.87 | TGFBR1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL6981739 | 0.77 | ADAM17 (0.38) | ADAM17CTSC | |
| SCHEMBL7818862 | 0.76 | ADAM17 (0.36) | ADAM17CTSC | |
| SCHEMBL6941953 | 0.76 | ADAM17 (0.39) | ADAM17MASP2CTSC | |
| SCHEMBL6984201 | 0.75 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL7811747 | 0.75 | ADAM17 (0.35) | ADAM17CTSC | |
| SCHEMBL7812777 | 0.75 | ADAM17 (0.36) | ADAM17CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |