Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5843596 | 0.99 | SHMT2 (0.49) | SHMT2POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6985243 | 0.94 | SHMT2 (0.52) | SHMT2POLBALDH1A1LMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5840917 | 0.93 | SHMT2 (0.51) | SHMT2POLBALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6985422 | 0.89 | SHMT2 (0.64) | SHMT2POLBALDH1A1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5840743 | 0.89 | SHMT2 (0.63) | SHMT2POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5842431 | 0.85 | SHMT2 (0.56) | SHMT2POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6980711 | 0.84 | MAPT (0.57) | POLBALDH1A1SMN1; SMN2L3MBTL1CACNA1G | |
| Hydrochloric Acid SCHEMBL5842053 | 0.83 | MAPT (0.56) | POLBALDH1A1SMN1; SMN2L3MBTL1CACNA1G | |
| SCHEMBL6983602 | 0.83 | SIGMAR1 (0.47) | ALDH1A1CACNA1G | |
| SCHEMBL6986873 | 0.83 | SHMT2 (0.44) | SHMT2SLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |