Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978613 | 0.86 | SMN1; SMN2 (0.79) | KDM4ESMN1; SMN2ALDH1A1KMT2AATM | |
| SCHEMBL3603304 | 0.83 | NPC1 (0.68) | KDM4ESMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3602994 | 0.82 | MAPT (0.59) | KDM4ESMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3604622 | 0.82 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL20530876 | 0.81 | VCP (0.56) | KDM4ESMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL6985901 | 0.78 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2ALDH1A1KMT2AATM | |
| SCHEMBL2754074 | 0.78 | KDM4E (0.78) | KDM4ESMN1; SMN2ALDH1A1KMT2AATM | |
| SCHEMBL23742077 | 0.77 | CA1 (0.55) | KDM4ESMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL12249036 | 0.77 | KDM4E (0.70) | KDM4ESMN1; SMN2ALDH1A1KMT2AATM | |
| SCHEMBL6984185 | 0.77 | SMN1; SMN2 (0.59) | KDM4ESMN1; SMN2ALDH1A1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934938-B1 | SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME | ZERIA PHARM CO LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6121301-A | ADMINISTERING TO PREVENT OR TREAT GASTROINTESTINAL DYSMOTILITY; COMPOUNDS SUCH AS 2-((N-(3-CYANOBENZOYL)AMINO)-4-((3-DIISOPROPYLAMINOPROPYL)AMINOCARBONYL)-1,3-THIAZOLE | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0934938-A1 | SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-11 | — | — | EP | disclosed |