Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2285389 | 0.82 | AMY1A (0.60) | KDM1AGAAL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL20530863 | 0.81 | SMN1; SMN2 (0.72) | GAAMAPTMAPK1GFERKDM4E | |
| SCHEMBL525682 | 0.81 | KDM1A (0.76) | VCPKDM1AGAAMAPTMAPK1 | |
| SCHEMBL5200233 | 0.81 | MAPT (0.68) | KDM1AGAAL3MBTL1MAPTMAPK1 | |
| SCHEMBL525812 | 0.81 | KDM1A (0.56) | KDM1AGAAL3MBTL1MAPTMAPK1 | |
| SCHEMBL4919827 | 0.81 | KDM1A (0.76) | KDM1AGAAL3MBTL1MAPTMAPK1 | |
| SCHEMBL6985089 | 0.81 | KDM4E (0.69) | GAAL3MBTL1MAPTMAPK1KDM4E | |
| SCHEMBL525271 | 0.79 | KDM1A (0.54) | VCPKDM1AGAAL3MBTL1MAPT | |
| SCHEMBL525597 | 0.77 | CSNK2A1 (0.65) | VCPGAAL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL525630 | 0.77 | CFTR (0.54) | KDM1AGAAL3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388425-B1 | AMINOAZOLE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2020-08-05 | — | — | EP | disclosed |
| US-10689354-B2 | Aminoazole derivative | TEIJIN PHARMA LIMITED (JP) | 2020-06-23 | — | — | US | disclosed |
| EP-3645531-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2020-05-06 | — | — | EP | disclosed |
| US-20200123147-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-04-23 | — | — | US | disclosed |
| US-20190031628-A1 | AMINOAZOLE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2019-01-31 | — | — | US | disclosed |
| WO-2019002074-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2019-01-03 | — | — | WO | disclosed |
| EP-3388425-A1 | AMINOAZOLE DERIVATIVE | Teijin Pharma Limited (JP) | 2018-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123147-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | VCP 4344/4885KDM1A 162/4885GAA 3644/4885 |
| US-10689354-B2 | Aminoazole derivative | AR, NR3C2, NR5A1 | VCP 4862/4885KDM1A 1693/4885GAA 4853/4885 |
| US-20190031628-A1 | AMINOAZOLE DERIVATIVE | AR, NR3C2, NR5A1 | VCP 4862/4885KDM1A 1693/4885GAA 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.