Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5840917 | 0.99 | SHMT2 (0.51) | SHMT2POLBMEN1KMT2ATSHR | |
| SCHEMBL6986043 | 0.94 | SHMT2 (0.50) | SHMT2POLBL3MBTL1LMNAATM | |
| Hydrochloric Acid SCHEMBL5843596 | 0.93 | SHMT2 (0.49) | SHMT2POLBL3MBTL1MAPTLMNA | |
| SCHEMBL5842431 | 0.83 | SHMT2 (0.56) | SHMT2POLBL3MBTL1LMNAALDH1A1 | |
| SCHEMBL6985422 | 0.83 | SHMT2 (0.64) | SHMT2POLBMEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5840743 | 0.82 | SHMT2 (0.63) | SHMT2POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL9129577 | 0.81 | MEN1 (0.60) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6986873 | 0.80 | SHMT2 (0.44) | SHMT2 | |
| SCHEMBL5841208 | 0.79 | SHMT2 (0.44) | SHMT2 | |
| Hydrochloric Acid SCHEMBL5840949 | 0.79 | SHMT2 (0.44) | SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |