Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5840743 | 0.99 | SHMT2 (0.63) | SHMT2NPSR1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6986043 | 0.89 | SHMT2 (0.50) | SHMT2NPSR1ALDH1A1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5843596 | 0.89 | SHMT2 (0.49) | SHMT2ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6980711 | 0.87 | MAPT (0.57) | ALDH1A1SMN1; SMN2MAPTKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5842053 | 0.86 | MAPT (0.56) | ALDH1A1SMN1; SMN2MAPTKMT2AL3MBTL1 | |
| SCHEMBL6981732 | 0.84 | MEN1 (0.54) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6985937 | 0.83 | NPSR1 (0.59) | NPSR1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6985243 | 0.83 | SHMT2 (0.52) | SHMT2NPSR1ALDH1A1LMNAMAPT | |
| SCHEMBL5842521 | 0.83 | SIGMAR1 (0.57) | L3MBTL1CACNA1G | |
| Hydrochloric Acid SCHEMBL5842390 | 0.83 | MEN1 (0.56) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |