Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | PLAU | P00749 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PKLR | P30613 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983430 | 0.85 | KEAP1 (0.61) | LMNASMN1; SMN2ALDH1A1PTPN2PTPN1 | |
| SCHEMBL8279501 | 0.81 | PLAU (0.65) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29549847 | 0.78 | PGR (0.77) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL20021987 | 0.78 | PGR (0.77) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28396503 | 0.78 | PGR (0.77) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6986320 | 0.76 | TSHR (0.60) | ALDH1A1PGRPTPN2PTPN1PTPN5 | |
| SCHEMBL808105 | 0.76 | ATM (0.72) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL9942088 | 0.76 | ATM (0.72) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL9942091 | 0.76 | ATM (0.68) | ATMPLAULMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL20021984 | 0.76 | ATM (0.72) | ATMPLAULMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1290264-A | Triazine angiogenesis inhibitors | ABBOTT LAB (US) | 2001-04-04 | — | — | CN | claimed |
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | claimed |
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | claimed |
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6288228-B1 | DIAMINOTRIAZINE DERIVATIVES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| CN-1290264-A | Triazine angiogenesis inhibitors | ABBOTT LAB (US) | 2001-04-04 | — | — | CN | disclosed |
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | disclosed |
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | disclosed |