Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.33 |
| ▸ | AOC2 | O75106 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985829 | 0.94 | POLB (0.37) | LMNAMAPK1HTTSMN1; SMN2POLB | |
| SCHEMBL7135238 | 0.84 | ADRA1B (0.44) | KMT2AALDH1A1CYP2C19ADRA1AADRA1B | |
| SCHEMBL6985013 | 0.82 | KMT2A (0.39) | POLBKMT2ATDP1KDM4EALDH1A1 | |
| SCHEMBL6987065 | 0.82 | POLB (0.39) | POLBKMT2ATDP1AOC2KDM4E | |
| SCHEMBL6986746 | 0.81 | SMN1; SMN2 (0.41) | HTTSMN1; SMN2POLBKMT2ASLC6A4 | |
| SCHEMBL6977033 | 0.81 | KMT2A (0.38) | POLBKMT2ATDP1KDM4EALDH1A1 | |
| SCHEMBL6981559 | 0.80 | ADRA1B (0.41) | POLBKMT2ATDP1L3MBTL1ADRA1B | |
| SCHEMBL4866678 | 0.80 | ADAMTS5 (0.38) | LMNAMAPK1HTTSMN1; SMN2POLB | |
| SCHEMBL6979427 | 0.79 | CYP2C19 (0.39) | SMN1; SMN2POLBKMT2ATDP1AOC2 | |
| SCHEMBL6986602 | 0.78 | KDM4E (0.41) | LMNASMN1; SMN2POLBKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |