Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ALPI | P09923 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979127 | 0.83 | KDM4E (0.41) | SCN10ANOS2NOS1NOS3ALDH1A1 | |
| SCHEMBL6753935 | 0.76 | SCN10A (0.38) | SCN10AAAK1MEN1HTTKMT2A | |
| SCHEMBL6987043 | 0.75 | SCN10A (0.35) | SCN10AAAK1ALPLALPIALPG | |
| SCHEMBL13544182 | 0.73 | DDAH1 (0.44) | NOS2NOS1NOS3HTTKMT2A | |
| SCHEMBL6756258 | 0.73 | ELANE (0.36) | SCN10AHTTALDH1A1 | |
| SCHEMBL6986516 | 0.71 | SCN10A (0.45) | SCN10AAAK1MEN1HTTKMT2A | |
| SCHEMBL431611 | 0.71 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1 | |
| SCHEMBL24312996 | 0.70 | KDM4E (0.41) | SCN10AHTTALDH1A1ALOX15CYP1A2 | |
| SCHEMBL11874941 | 0.70 | AR (0.35) | — | |
| SCHEMBL22962142 | 0.69 | KDM4E (0.40) | SCN10AHTTALDH1A1CYP1A2ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | SCN10A 3312/4885AAK1 2672/4885NOS2 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.