Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629170 | 0.88 | CYP1A2 (0.54) | KIF11CYP2C19CYP1A2CYP2C9ATM | |
| SCHEMBL27590092 | 0.76 | KIF11 (0.46) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL7019811 | 0.74 | MEN1 (0.51) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL9447405 | 0.74 | KIF11 (0.46) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5308339 | 0.73 | SLC6A2 (0.55) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL16835570 | 0.73 | KIF11 (0.49) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL6682555 | 0.72 | KIF11 (0.50) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL10360563 | 0.72 | KIF11 (0.47) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL13824798 | 0.72 | KIF11 (0.47) | KIF11MEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL29271946 | 0.71 | KIF11 (0.45) | KIF11MEN1KMT2ACYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | claimed |