Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399532 | 0.77 | GAA (0.56) | GAATSHRALDH1A1KMT2AGRM2 | |
| SCHEMBL6987105 | 0.77 | GAA (0.56) | GAATSHRALDH1A1KMT2AGRM2 | |
| SCHEMBL27781493 | 0.77 | LMNA (0.63) | GAATSHRKMT2AGRM2LMNA | |
| SCHEMBL7992838 | 0.75 | RECQL (0.43) | GAAALDH1A1HTTNAPRTLMNA | |
| SCHEMBL6987044 | 0.74 | GAA (0.52) | GAATSHRALDH1A1KMT2AGRM2 | |
| SCHEMBL2029473 | 0.72 | CRHBP (0.51) | TSHRALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL24069261 | 0.72 | GAA (0.50) | GAATSHRALDH1A1KMT2AGRM2 | |
| SCHEMBL3897903 | 0.71 | ALDH1A1 (0.44) | GAAALDH1A1KMT2ALMNACRHBP | |
| SCHEMBL9104852 | 0.71 | GAA (0.71) | GAATSHRALDH1A1KMT2AHTT | |
| SCHEMBL7866104 | 0.70 | PKM (0.60) | GAATSHRALDH1A1KMT2ANAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324999-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030927-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2002-04-18 | — | — | WO | disclosed |