Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 3/20 | 0.79 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.69 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.69 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.69 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11404089 | 0.90 | HMOX1 (0.91) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL9996131 | 0.88 | HMOX1 (1.00) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| Hydrochloric Acid SCHEMBL410683 | 0.87 | HMOX1 (0.97) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL28844163 | 0.87 | HMOX1 (0.97) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL570591 | 0.83 | CYP11B1 (0.66) | HMOX1CYP19A1CYP11B1TBXAS1KMT2A | |
| SCHEMBL16719036 | 0.82 | CYP19A1 (0.81) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL27460992 | 0.82 | TBXAS1 (0.60) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL10788342 | 0.82 | TBXAS1 (0.65) | HMOX1CYP19A1TBXAS1KMT2A | |
| SCHEMBL6987156 | 0.82 | CYP19A1 (0.69) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL4316370 | 0.82 | CYP11B1 (0.69) | HMOX1CYP19A1CYP11B1CYP11B2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| CN-1070368-C | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | JANSSEN PHARMACEUTICA NV (BE) | 2001-09-05 | — | — | CN | disclosed |
| CN-1142360-A | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | YUAN ANLING (CN) | 1997-02-12 | — | — | CN | disclosed |
| CN-1033586-C | Imidazo [2, 1-b ] [3] benzazepine derivatives and their use as anti-inflammatory agents | JANSSEN PHARMACEUTICA NV (BE) | 1996-12-18 | — | — | CN | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| CN-1068118-A | Imidazo [2, 1-b ] [3] benzazepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 1993-01-20 | — | — | CN | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |