Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250601 | 0.96 | ADORA2A (0.72) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL30205277 | 0.96 | ADORA2A (0.72) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL6977514 | 0.86 | ADORA1 (0.91) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL4201340 | 0.86 | L3MBTL1 (0.54) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL18468590 | 0.86 | L3MBTL1 (0.54) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL4031522 | 0.86 | MEN1 (0.54) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL18468613 | 0.86 | L3MBTL1 (0.54) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL6334237 | 0.86 | ADORA1 (0.82) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL16332656 | 0.86 | L3MBTL1 (0.54) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL29385431 | 0.86 | L3MBTL1 (0.54) | ADORA1ADORA2AADORA3ADORA2BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6288228-B1 | DIAMINOTRIAZINE DERIVATIVES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | disclosed |