Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842572 | 0.99 | MEN1 (0.40) | SLC29A1SIGMAR1SHMT2MEN1LMNA | |
| SCHEMBL6984251 | 0.85 | HTR7 (0.41) | SIGMAR1SHMT2CHRM3KCNH2 | |
| Hydrochloric Acid SCHEMBL5840216 | 0.84 | HTR7 (0.41) | SIGMAR1CHRM3KCNH2 | |
| SCHEMBL6986054 | 0.82 | SIGMAR1 (0.46) | SLC29A1SIGMAR1SHMT2MEN1LMNA | |
| Hydrochloric Acid SCHEMBL5842883 | 0.81 | SIGMAR1 (0.46) | SLC29A1SIGMAR1SHMT2MEN1LMNA | |
| SCHEMBL5842908 | 0.81 | FGFR3 (0.42) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5841494 | 0.80 | FGFR3 (0.43) | SIGMAR1 | |
| SCHEMBL5842277 | 0.80 | SLC29A1 (0.42) | SLC29A1SIGMAR1MEN1KMT2A | |
| SCHEMBL6985289 | 0.79 | SIGMAR1 (0.40) | SIGMAR1MEN1KMT2ACHRM3KCNH2 | |
| Hydrochloric Acid SCHEMBL5842442 | 0.78 | HTR7 (0.41) | SIGMAR1MEN1KMT2ACHRM3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |