Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842442 | 0.99 | HTR7 (0.41) | SIGMAR1HTR7MEN1KMT2ACHRM2 | |
| SCHEMBL5842908 | 0.86 | FGFR3 (0.42) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5841494 | 0.85 | FGFR3 (0.43) | SIGMAR1 | |
| SCHEMBL6984251 | 0.83 | HTR7 (0.41) | SIGMAR1HTR7CHRM2CHRM4ABCB1 | |
| SCHEMBL5842277 | 0.83 | SLC29A1 (0.42) | SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5840216 | 0.82 | HTR7 (0.41) | SIGMAR1HTR7CHRM2CHRM4ABCB1 | |
| SCHEMBL6986270 | 0.79 | SLC29A1 (0.41) | SIGMAR1MEN1KMT2ACHRM3KCNH2 | |
| Hydrochloric Acid SCHEMBL5842572 | 0.78 | MEN1 (0.40) | SIGMAR1MEN1KMT2ACHRM3KCNH2 | |
| SCHEMBL6986839 | 0.78 | ALDH1A1 (0.43) | SIGMAR1 | |
| SCHEMBL6985106 | 0.76 | SIGMAR1 (0.43) | SIGMAR1CHRM2CHRM4ABCB1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |