Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27476501 | 1.00 | KDR (0.40) | KDRCRHR1HDAC1HDAC6HDAC3 | |
| SCHEMBL1036254 | 0.83 | CASP1 (0.45) | KDRCRHR1MCHR1 | |
| SCHEMBL1035202 | 0.79 | POLB (0.49) | CRHR1 | |
| SCHEMBL915781 | 0.78 | SMN1; SMN2 (0.48) | SORT1L3MBTL1 | |
| SCHEMBL29378297 | 0.78 | SMN1; SMN2 (0.48) | SORT1L3MBTL1 | |
| SCHEMBL29608609 | 0.78 | HCAR2 (0.36) | KDRCRHR1MCHR1L3MBTL1 | |
| SCHEMBL1160933 | 0.78 | HCAR2 (0.36) | KDRCRHR1MCHR1L3MBTL1 | |
| SCHEMBL1031100 | 0.78 | CRHR1 (0.60) | CRHR1MCHR1 | |
| SCHEMBL6774259 | 0.76 | RAB9A (0.61) | SORT1L3MBTL1 | |
| SCHEMBL9592081 | 0.76 | POLB (0.55) | CRHR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779281-B1 | ISOXAZOLES | SANKYO CO (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-6096771-A | ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5965591-A | MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0779281-A1 | ISOXAZOLES | SANKYO COMPANY LIMITED (JP) | 1997-06-18 | — | — | EP | disclosed |