Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782503 | 0.86 | PDGFRB (0.54) | LMNAPDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL395110 | 0.81 | NPC1 (0.57) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL25090641 | 0.77 | WDR5 (0.61) | LMNAALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL12786341 | 0.77 | NPC1 (0.60) | LMNAPDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL28119259 | 0.77 | NPC1 (0.60) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL775333 | 0.75 | NPC1 (0.61) | LMNAPDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL1262124 | 0.73 | — | — | |
| SCHEMBL9099501 | 0.72 | NPC1 (0.80) | LMNAPDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL9098509 | 0.72 | NPC1 (0.80) | LMNAPDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL9098395 | 0.72 | NPC1 (0.80) | LMNAPDGFRBPDGFRANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282614-A1 | HYDROXAMIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001087870-A1 | HYDROXAMIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |