Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349175 | 0.85 | MAPK1 (0.36) | RECQLTDP1ALDH1A1KDM4EALOX5 | |
| SCHEMBL15390929 | 0.80 | ADORA2A (0.34) | RECQLTDP1ALDH1A1KDM4EALOX5 | |
| SCHEMBL904515 | 0.79 | RECQL (0.54) | RECQLTDP1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL24738810 | 0.75 | CYP2D6 (0.37) | RECQLCYP2D6CYP2C19S1PR2POLB | |
| SCHEMBL31047280 | 0.75 | RECQL (0.40) | RECQLCYP2D6CYP2C19S1PR2FFAR1 | |
| SCHEMBL27704309 | 0.75 | TDP1 (0.39) | RECQLTDP1S1PR2FFAR1LOX | |
| SCHEMBL5751544 | 0.75 | ALDH1A1 (0.45) | RECQLALDH1A1KDM4EGAAMAPT | |
| SCHEMBL6987047 | 0.75 | S1PR2 (0.37) | RECQLALDH1A1S1PR2FFAR1LOX | |
| SCHEMBL15517369 | 0.75 | FFAR1 (0.33) | RECQLS1PR2FFAR1LOXLOXL3 | |
| SCHEMBL63871 | 0.74 | TDP1 (0.53) | TDP1ALDH1A1KDM4EALOX5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |