Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986513 | 0.76 | ADRA1A (0.51) | SMN1; SMN2TAAR1ADRA1A | |
| SCHEMBL27982921 | 0.76 | KEAP1 (0.58) | SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL4662893 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL25223925 | 0.72 | KEAP1 (0.68) | SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL4901454 | 0.71 | TAAR1 (1.00) | TAAR1ADRA1A | |
| SCHEMBL15621204 | 0.71 | KEAP1 (0.61) | SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL11618400 | 0.71 | KMT2A (0.60) | — | |
| SCHEMBL15621510 | 0.70 | KEAP1 (0.59) | SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL24732099 | 0.70 | HRH4 (0.73) | SMN1; SMN2TAAR1 | |
| SCHEMBL29540801 | 0.70 | KEAP1 (0.70) | SMN1; SMN2LMNAKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324999-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030927-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2002-04-18 | — | — | WO | disclosed |