Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867906 | 0.85 | ALDH1A1 (0.54) | PTPRBPTPN11ALDH1A1KMT2AMEN1 | |
| SCHEMBL6990627 | 0.81 | ATM (0.48) | ALDH1A1ATMNPY1RSMN1; SMN2NPSR1 | |
| SCHEMBL5868120 | 0.80 | KMT2A (0.52) | PTPRBPTPN11ALDH1A1KMT2AMEN1 | |
| SCHEMBL5868093 | 0.78 | SMYD3 (0.45) | PTPRBPTPN11KMT2AMEN1KDM4E | |
| SCHEMBL2212963 | 0.74 | LMNA (0.52) | PTPRBPTPN11ALDH1A1KMT2AMEN1 | |
| SCHEMBL5868024 | 0.73 | KDM4E (0.58) | ALDH1A1KMT2AMEN1LMNAKDM4E | |
| SCHEMBL5868022 | 0.73 | GPR119 (0.56) | ALDH1A1KMT2AMEN1LMNATHRB | |
| SCHEMBL14655077 | 0.72 | KMT2A (0.56) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL29744615 | 0.72 | ALDH1A1 (0.63) | ALDH1A1KDM4EPKMGPR119NPC1 | |
| SCHEMBL1673587 | 0.72 | ALDH1A1 (0.63) | ALDH1A1KDM4EPKMGPR119NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289954-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096303-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |