Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5868195 | 0.83 | HSD17B10 (0.54) | NPC1RAB9AHDAC1HDAC6TSHR | |
| SCHEMBL593297 | 0.76 | HTR4 (0.58) | ATMNPC1RAB9AKCNA3CDK1 | |
| Hydrochloric Acid SCHEMBL594135 | 0.75 | HTR4 (0.57) | ATMNPC1RAB9ACDK1CDK4 | |
| SCHEMBL1753596 | 0.72 | RAB9A (0.55) | ATMNPC1RAB9AKCNA3ALDH1A1 | |
| SCHEMBL5517147 | 0.72 | TSHR (0.71) | NPC1RAB9ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL5867874 | 0.72 | SMYD3 (0.53) | HDAC1HDAC6ALDH1A1HPGDPDK1 | |
| SCHEMBL5482447 | 0.71 | RAB9A (0.56) | ATMNPC1RAB9AALDH1A1GAA | |
| SCHEMBL10107580 | 0.70 | SLC6A4 (0.64) | TSHRCDK1CDK4CCND1CDK2 | |
| SCHEMBL12231088 | 0.70 | ALDH1A1 (0.54) | NPC1RAB9ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL1753490 | 0.69 | DRD4 (0.55) | NPC1RAB9ACDK1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289954-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001096303-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |