Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.71 |
| ▸ | RAB9A | P51151 | 7/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | CTSV | O60911 | 1/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15073406 | 0.80 | CYP19A1 (0.72) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9180105 | 0.79 | ALDH1A1 (0.62) | HPGDKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL13038842 | 0.78 | CTSV (0.69) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6534180 | 0.76 | HPGD (1.00) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30935678 | 0.76 | HPGD (1.00) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2799465 | 0.75 | HPGD (1.00) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30573072 | 0.75 | L3MBTL1 (0.44) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL26607165 | 0.75 | L3MBTL1 (0.44) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16923633 | 0.74 | CHUK (0.57) | HPGDKDM4EALDH1A1NPC1MEN1 | |
| SCHEMBL16382899 | 0.74 | CYP19A1 (0.63) | HPGDKDM4ERAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276739-A2 | HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME | Bristol-Myers Squibb Company (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001081340-A2 | HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |