Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988582 | 0.84 | CYP17A1 (0.35) | KDM4ECYP19A1CYP17A1SMN1; SMN2LMNA | |
| SCHEMBL6498908 | 0.83 | KMT2A (0.46) | KDM4ECYP19A1SMN1; SMN2 | |
| SCHEMBL6505294 | 0.78 | ALDH1A1 (0.42) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL360712 | 0.77 | CFTR (0.57) | TBXAS1KDM4ECFTRSLC6A2SLC6A4 | |
| SCHEMBL6509102 | 0.77 | ADRB3 (0.38) | CYP19A1MAPTADRB3SMN1; SMN2LMNA | |
| SCHEMBL6503338 | 0.75 | CYP19A1 (0.62) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL6502611 | 0.75 | POLB (0.51) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL6498870 | 0.74 | ALDH1A1 (0.49) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7492214 | 0.74 | MAPK1 (0.54) | — | |
| SCHEMBL8191216 | 0.73 | PTGS2 (0.48) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333827-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-1328522-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002032377-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| WO-2002032373-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2002-04-25 | — | — | WO | disclosed |