SCHEMBL6987779

SCHEMBL6987779

COc1ccc(-c2c(C(C)(C)C)cnn2-c2ccccc2)nn1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
LMNA P02545 2/20 0.39
HTT P42858 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
GAA P10253 3/20 0.38
HIF1A Q16665 2/20 0.35
KDM4E B2RXH2 3/20 0.35
MPO P05164 1/20 0.35
OXTR P30559 1/20 0.34
MAPT P10636 2/20 0.34
NPBWR1 P48145 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HPGDS O60760 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6981888 0.71 PDE10A (0.46) ALDH1A1LMNANPSR1GAAMPO
SCHEMBL6983980 0.70 HIF1A (0.40) ALDH1A1HTTNPSR1GAAHIF1A
SCHEMBL10139089 0.69 MAPK1 (0.51) ALDH1A1HTTKDM4EMAPTSMN1; SMN2
SCHEMBL15627329 0.69 SMN1; SMN2 (0.45) ALDH1A1LMNAHTTNPSR1GAA
SCHEMBL23403086 0.67 MAPK1 (0.42) ALDH1A1LMNAHTTGAAKDM4E
SCHEMBL10183509 0.67 NPC1 (0.54) ALDH1A1HTTNPSR1GAAKDM4E
SCHEMBL14447510 0.67 RAB9A (0.49) ALDH1A1LMNAHTTNPSR1GAA
SCHEMBL17111160 0.66 RAB9A (0.54) ALDH1A1LMNAKDM4EMAPTCYP1A2
SCHEMBL820782 0.65 SMN1; SMN2 (0.56) ALDH1A1LMNAHTTNPSR1KDM4E
SCHEMBL6985834 0.64 ALDH1A1 (0.51) ALDH1A1LMNAHTTNPSR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313733-A1 PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-05-28 EP disclosed
WO-2002018382-A1 PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-03-07 WO disclosed