Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983368 | 0.74 | LMNA (0.38) | ALDH1A1LMNANPSR1HTTNR1I2 | |
| SCHEMBL7370829 | 0.73 | NR3C2 (0.44) | ALDH1A1NPSR1GAAKDM4EHTR6 | |
| SCHEMBL7369553 | 0.73 | HTT (0.47) | ALDH1A1LMNANPSR1HTTGAA | |
| SCHEMBL27343295 | 0.73 | CYP2C9 (0.45) | LMNANPSR1TP53POLBPKM | |
| SCHEMBL6821442 | 0.70 | HTR6 (0.37) | ALDH1A1LMNANPSR1HTTGAA | |
| SCHEMBL10354233 | 0.68 | HTR6 (0.62) | ALDH1A1KDM4EHTR6TP53PKM | |
| SCHEMBL7370147 | 0.67 | PTGS1 (0.38) | ALDH1A1LMNANPSR1HTTGAA | |
| SCHEMBL27968340 | 0.65 | GAA (0.51) | ALDH1A1LMNANPSR1HTTGAA | |
| SCHEMBL28295008 | 0.65 | ALDH1A1 (0.49) | ALDH1A1LMNANPSR1HTTGAA | |
| SCHEMBL6987779 | 0.64 | ALDH1A1 (0.39) | ALDH1A1LMNANPSR1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |