Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.58 |
| ▸ | DAO | P14920 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988070 | 0.87 | MTNR1A (0.51) | MCL1DAOALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7902953 | 0.83 | NR1H2 (0.55) | MCL1DAOALDH1A1TSHR | |
| SCHEMBL29781083 | 0.83 | NR1H2 (0.55) | MCL1DAOALDH1A1TSHR | |
| SCHEMBL4222282 | 0.81 | MCL1 (0.64) | MCL1DAOALDH1A1TSHRCCR2 | |
| SCHEMBL29780995 | 0.81 | DAO (0.65) | MCL1DAOALDH1A1TSHRCCR2 | |
| SCHEMBL3638561 | 0.81 | DAO (0.65) | MCL1DAOALDH1A1TSHRCCR2 | |
| SCHEMBL20909818 | 0.80 | MCL1 (0.50) | MCL1DAOALDH1A1TSHRL3MBTL1 | |
| SCHEMBL3831363 | 0.79 | KDM1A (0.56) | MCL1DAOALDH1A1TSHRCCR2 | |
| SCHEMBL14398966 | 0.79 | MCL1 (0.60) | MCL1DAOALDH1A1TSHRCCR2 | |
| SCHEMBL17075022 | 0.79 | L3MBTL1 (0.47) | MCL1DAOALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335917-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | Lilly Icos LLC (US) | 2003-08-20 | — | — | EP | claimed |
| WO-2002028859-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | LILLY ICOS LLC (US) | 2002-04-11 | — | — | WO | claimed |