Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994067 | 0.93 | RAB9A (0.41) | CTSKRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6294364 | 0.91 | TP53 (0.38) | CTSKRAB9AESRRGLMNAHPGD | |
| SCHEMBL6993081 | 0.91 | CTSK (0.35) | CTSKRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6989694 | 0.91 | KMT2A (0.40) | SMN1; SMN2NPC1MEN1KMT2ALMNA | |
| SCHEMBL6997966 | 0.90 | MEN1 (0.34) | MEN1KMT2ADEGS1OPRM1OPRD1 | |
| SCHEMBL6992764 | 0.89 | HPGD (0.39) | CTSKRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6993342 | 0.88 | KMT2A (0.40) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL6998484 | 0.87 | TRPV1 (0.39) | — | |
| SCHEMBL6989614 | 0.85 | TP53 (0.47) | CTSKRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6988021 | 0.85 | NPC1 (0.39) | SMN1; SMN2NPC1KMT2ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |