Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989694 | 0.93 | KMT2A (0.40) | NPC1HPGDKMT2ASMN1; SMN2TP53 | |
| SCHEMBL6994067 | 0.92 | RAB9A (0.41) | NPC1KMT2ASMN1; SMN2TP53LMNA | |
| SCHEMBL6986470 | 0.91 | HPGD (0.38) | NPC1HPGDKMT2ASMN1; SMN2TP53 | |
| SCHEMBL6989614 | 0.89 | TP53 (0.47) | NPC1KMT2ASMN1; SMN2TP53MAPT | |
| SCHEMBL6990244 | 0.88 | TP53 (0.38) | KMT2AUTS2RTP53MAPTPOLB | |
| SCHEMBL6993839 | 0.86 | HTR1A (0.39) | NPC1HPGDKMT2ASMN1; SMN2TP53 | |
| SCHEMBL6988915 | 0.85 | IDO1 (0.42) | NPC1KMT2ASMN1; SMN2TP53LMNA | |
| SCHEMBL6991739 | 0.85 | TRPV1 (0.38) | TP53LMNA | |
| SCHEMBL6988745 | 0.85 | CTSK (0.35) | NPC1HPGDKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6992764 | 0.83 | HPGD (0.39) | NPC1HPGDKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |