Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996937 | 0.93 | TP53 (0.40) | HPGDSLC6A3GLP1RGCGRCTSK | |
| SCHEMBL6986470 | 0.92 | HPGD (0.38) | HPGDSLC6A3GLP1RGCGRSMN1; SMN2 | |
| SCHEMBL6992598 | 0.91 | AKT1 (0.38) | HPGDSLC6A3GLP1RGCGRMEN1 | |
| SCHEMBL6994067 | 0.91 | RAB9A (0.41) | CTSKRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6988745 | 0.89 | CTSK (0.35) | HPGDCTSKRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6993081 | 0.89 | CTSK (0.35) | CTSKRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7144829 | 0.88 | TRPV1 (0.42) | GCGRPTGDR2TAOK1TAOK3CCR3 | |
| SCHEMBL6989614 | 0.83 | TP53 (0.47) | GCGRCTSKRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6988021 | 0.83 | NPC1 (0.39) | HPGDSMN1; SMN2KMT2ANPC1LMNA | |
| SCHEMBL6702836 | 0.82 | CTSL (0.41) | CTSKTAOK1TAOK3CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |