Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320229 | 0.87 | DRD2 (0.48) | DRD2HTR2AHTR1ASLC6A4 | |
| SCHEMBL1545123 | 0.79 | HTR2A (0.60) | HTR2CDRD2HTR2ADRD3ACHE | |
| SCHEMBL6990695 | 0.76 | DRD2 (0.48) | HTR2CDRD2HTR2AHTR6SLC6A4 | |
| SCHEMBL1545818 | 0.76 | ACHE (0.72) | HTR2CDRD2HTR2AACHESLC6A4 | |
| SCHEMBL1545271 | 0.76 | DRD2 (0.61) | HTR2CDRD2HTR2AHTR1ADRD1 | |
| SCHEMBL9683993 | 0.73 | ACHE (0.62) | HTR2CDRD2HTR2AACHESLC6A4 | |
| SCHEMBL9133222 | 0.73 | DRD2 (0.61) | HTR2CDRD2HTR2AHTR1ADRD1 | |
| SCHEMBL9683889 | 0.71 | DRD2 (0.61) | HTR2CDRD2HTR2AHTR1AACHE | |
| Fumaric Acid SCHEMBL1545971 | 0.71 | ACHE (0.61) | DRD2HTR2AACHESLC6A4 | |
| Fumaric Acid SCHEMBL1545969 | 0.71 | ACHE (0.61) | DRD2HTR2AACHESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |