Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | HTR2A | P28223 | 7/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321111 | 0.80 | HTR2C (0.45) | DRD2SLC6A4ADRA1AHTR2CHTR2A | |
| SCHEMBL11107203 | 0.77 | ADRA2A (0.55) | DRD2ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL8320229 | 0.77 | DRD2 (0.48) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL11104894 | 0.76 | HTR2C (0.54) | DRD2ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL6989097 | 0.76 | HTR2C (0.49) | DRD2SLC6A4HTR2CHTR2AHTR6 | |
| SCHEMBL6797367 | 0.76 | HTR2A (0.43) | DRD2HTR2CHTR2AHRH1LMNA | |
| SCHEMBL6906280 | 0.75 | HTR1A (0.61) | DRD2SLC6A4HTR2CHTR2ASMN1; SMN2 | |
| SCHEMBL6782174 | 0.75 | HTR2A (0.51) | DRD2HTR2CHTR2AHRH1LMNA | |
| SCHEMBL7038063 | 0.75 | HTR2A (0.42) | DRD2HTR2CHTR2AHRH1LMNA | |
| SCHEMBL3026960 | 0.73 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0932609-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1998016530-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |