Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989097 | 0.87 | HTR2C (0.49) | DRD2SLC6A4HTR1AHTR2A | |
| SCHEMBL6990695 | 0.77 | DRD2 (0.48) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL8788480 | 0.77 | ACHE (0.45) | DRD2SLC6A4HTR2A | |
| SCHEMBL8787574 | 0.76 | DRD2 (0.47) | DRD2SLC6A4ADRA1AHTR1AHTR2A | |
| SCHEMBL9522190 | 0.72 | HTR1A (0.53) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL6993728 | 0.70 | DRD2 (0.48) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL6991016 | 0.69 | DRD2 (0.60) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL6994156 | 0.69 | DRD2 (0.50) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL9739413 | 0.68 | HTR1A (0.53) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL6991545 | 0.68 | DRD2 (0.49) | DRD2SLC6A4ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1998016530-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | claimed |