Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987934 | 0.96 | PTGS1 (0.52) | PTGS1PTGS2MAPK14BRD4 | |
| SCHEMBL6994222 | 0.81 | NISCH (0.45) | MAPK14ALDH1A1 | |
| SCHEMBL6991232 | 0.78 | BRD4 (0.57) | HSD11B1MAPTALDH1A1BRD4 | |
| SCHEMBL6998947 | 0.78 | BRD4 (0.54) | PTGS1PTGS2HSD11B1ALDH1A1LMNA | |
| SCHEMBL6994229 | 0.78 | TSHR (0.47) | MAPTLMNA | |
| SCHEMBL6993952 | 0.77 | HSD11B1 (0.59) | HSD11B1BRD4 | |
| SCHEMBL7000563 | 0.74 | BRD4 (0.59) | MAPTALDH1A1BRD4 | |
| SCHEMBL6998482 | 0.74 | CDKN1A (0.44) | PTGS1PTGS2BRD4 | |
| SCHEMBL6992970 | 0.73 | BRD4 (0.56) | HSD11B1ALDH1A1LMNABRD4 | |
| SCHEMBL2537130 | 0.69 | MAPK14 (0.45) | PTGS1PTGS2MAPK14HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | claimed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | claimed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | claimed |
| JP-11228538-A | — | — | None | — | — | JP | disclosed |
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| JP-H11228538-A | NEW PYPROLE COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | ADIR | 1999-08-24 | — | — | JP | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |