Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989207 | 0.82 | KMT2A (0.45) | CYP2C9CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL6989108 | 0.78 | NPC1 (0.45) | CYP2D6CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL5501851 | 0.78 | LMNA (0.57) | MEN1KMT2AALDH1A1L3MBTL1POLB | |
| SCHEMBL6988042 | 0.73 | ALDH1A1 (0.48) | CYP2D6CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL1169478 | 0.72 | ALDH1A1 (0.43) | CYP2D6CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL1169479 | 0.72 | ALDH1A1 (0.43) | CYP2D6CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL1169481 | 0.72 | ALDH1A1 (0.43) | CYP2D6CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL5200239 | 0.71 | CYP2C9 (0.66) | CYP2D6CYP2C9CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL6990063 | 0.70 | KMT2A (0.43) | CYP2C9CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL6990380 | 0.67 | KMT2A (0.40) | CYP2C9CYP2C19MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |