Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655445 | 0.80 | CYP2D6 (0.72) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL24812582 | 0.77 | CYP2D6 (0.62) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL5512457 | 0.77 | CYP2D6 (0.68) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL5652601 | 0.77 | CYP2D6 (0.79) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL7915450 | 0.77 | CYP2D6 (0.56) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL28588864 | 0.77 | CYP2D6 (0.72) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL15018169 | 0.76 | CYP2D6 (0.66) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL26242973 | 0.76 | CYP2D6 (0.66) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL15009831 | 0.76 | CYP2C9 (0.66) | CYP2C9CYP2C19CYP2D6TP53NPC1 | |
| SCHEMBL9289455 | 0.75 | CYP2D6 (0.55) | CYP2C9CYP2C19CYP2D6NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791121-B1 | BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2016-08-03 | — | — | EP | disclosed |
| US-8524745-B2 | Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20130150413-A1 | BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-7449447-B2 | Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| EP-1869023-A1 | NEW TRICYCLIC ANGIOTENSIN II AGONISTS | Vicore Pharma AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| EP-1869009-A1 | NEW BICYCLIC ANGIOTENSIN II AGONISTS | Vicore Pharma AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| US-20070203183-A1 | Diaryl piperidines as CB1 modulators | SCHERING CORPORATION | 2007-08-30 | — | — | US | disclosed |
| WO-2006109048-A1 | NEW TRICYCLIC ANGIOTENSIN II AGONISTS | VICORE PHARMA AB (SE) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006109058-A1 | NEW BICYCLIC ANGIOTENSIN II AGONISTS | VICORE PHARMA AB (SE) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203183-A1 | Diaryl piperidines as CB1 modulators | CNR1, CNR2, GPR119 | CYP2C9 1090/4885CYP2C19 902/4885CYP2D6 1103/4885 |
| US-20130150413-A1 | BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | CCR5, CCR2, CX3CR1 | CYP2C9 3030/4885CYP2C19 3083/4885CYP2D6 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.