Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992252 | 0.85 | FABP4 (0.43) | HCRTR2HCRTR1CYP3A4SCD5JAK1 | |
| SCHEMBL6990139 | 0.85 | SCD5 (0.53) | HCRTR2HCRTR1CYP3A4SCD5 | |
| SCHEMBL6987311 | 0.82 | FABP4 (0.45) | HCRTR2HCRTR1CYP3A4SCD5HRH3 | |
| SCHEMBL6987290 | 0.82 | HCRTR1 (0.48) | HCRTR2HCRTR1CYP3A4SCD5 | |
| SCHEMBL6987244 | 0.80 | HCRTR1 (0.50) | HCRTR2HCRTR1CYP3A4SCD5 | |
| SCHEMBL21078209 | 0.78 | KDM4E (0.47) | HCRTR2HCRTR1SCD5JAK1DPP4 | |
| SCHEMBL2477683 | 0.76 | ALDH1A1 (0.49) | — | |
| SCHEMBL17888319 | 0.74 | JAK1 (0.51) | HCRTR2HCRTR1CYP3A4JAK1 | |
| SCHEMBL21078251 | 0.73 | JAK1 (0.46) | HCRTR2HCRTR1CYP3A4JAK1DPP4 | |
| SCHEMBL6990119 | 0.72 | HSP90AA1 (0.48) | SCD5GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889683-B2 | Substituted quinoxalines as inhibitors of fatty acid binding protein | MERCK SHARP & DOHME CORP. (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889683-B2 | Substituted quinoxalines as inhibitors of fatty acid binding protein | MERCK SHARP & DOHME CORP. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | MERCK SHARP & DOHME LLC | 2012-05-17 | — | — | US | disclosed |
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | MERCK SHARP & DOHME LLC | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | FABP4, FABP1, FABP3 | HCRTR2 3592/4885HCRTR1 4346/4885CYP3A4 2192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.