Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700153 | 0.83 | TSHR (0.55) | TSHRNPSR1SLC18A2L3MBTL1TDP1 | |
| SCHEMBL19398219 | 0.80 | KMT2A (0.39) | TSHRNPSR1SLC18A2KMT2ACA1 | |
| SCHEMBL4514045 | 0.74 | TSHR (0.44) | TSHRNPSR1 | |
| SCHEMBL8803919 | 0.74 | L3MBTL1 (0.36) | TSHRPPARGL3MBTL1TDP1MAPK1 | |
| SCHEMBL8802238 | 0.74 | TSHR (0.35) | TSHRNPSR1PPARGL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL4514461 | 0.73 | TSHR (0.47) | TSHRNPSR1 | |
| Hydrochloric Acid SCHEMBL3878664 | 0.73 | TSHR (0.47) | TSHRNPSR1 | |
| SCHEMBL699685 | 0.73 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2KMT2A | |
| SCHEMBL17748955 | 0.72 | GAA (0.34) | TSHRPPARGL3MBTL1TDP1MAPK1 | |
| SCHEMBL1967366 | 0.71 | TSHR (0.41) | TSHRNPSR1PPARGL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421824-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |