Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700153 | 0.80 | TSHR (0.55) | TSHRL3MBTL1TDP1NPSR1 | |
| SCHEMBL3283792 | 0.79 | TSHR (0.38) | TSHRALDH1A1HSD17B10DRD2DRD4 | |
| SCHEMBL19398219 | 0.74 | KMT2A (0.39) | TSHRALDH1A1NPSR1 | |
| SCHEMBL17674692 | 0.72 | TSHR (0.39) | TSHRALDH1A1HSD17B10DRD2DRD4 | |
| SCHEMBL10517467 | 0.71 | MAPKAPK2 (0.47) | TSHRALDH1A1HSD17B10DRD2DRD4 | |
| SCHEMBL18938979 | 0.69 | GID4 (0.41) | TSHRALDH1A1HSD17B10DRD2NPSR1 | |
| SCHEMBL9852994 | 0.69 | TSHR (0.57) | TSHRNPSR1 | |
| SCHEMBL8802238 | 0.68 | TSHR (0.35) | TSHRL3MBTL1TDP1ALDH1A1MAPK1 | |
| SCHEMBL8803919 | 0.68 | L3MBTL1 (0.36) | TSHRL3MBTL1TDP1MAPK1CYP3A4 | |
| SCHEMBL4789768 | 0.68 | TSHR (0.45) | TSHRL3MBTL1TDP1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011071570-A1 | NOVEL OXADIAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-16 | — | — | WO | disclosed |