Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 12/20 | 0.35 |
| ▸ | MMP3 | P08254 | 11/20 | 0.35 |
| ▸ | MMP1 | P03956 | 10/20 | 0.35 |
| ▸ | MMP8 | P22894 | 7/20 | 0.35 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980963 | 0.85 | MMP1 (0.36) | BMP1MMP2MMP3MMP1MMP8 | |
| SCHEMBL6987387 | 0.84 | BMP1 (0.36) | BMP1MMP2MMP3MMP1MMP8 | |
| SCHEMBL6980442 | 0.84 | MMP1 (0.42) | MMP2MMP3MMP1MMP8MMP13 | |
| SCHEMBL6982620 | 0.81 | BMP1 (0.39) | BMP1MMP2MMP1MMP8MMP13 | |
| SCHEMBL6987397 | 0.81 | BMP1 (0.37) | BMP1MMP2MMP3MMP1MMP8 | |
| SCHEMBL6982401 | 0.79 | APP (0.37) | BMP1MMP2MMP3MMP1MMP8 | |
| SCHEMBL6982583 | 0.78 | ADAM17 (0.51) | MMP2MMP3MMP1MMP8MMP13 | |
| SCHEMBL6983569 | 0.78 | ADAM17 (0.48) | MMP2MMP3MMP1MMP8MMP13 | |
| SCHEMBL6983204 | 0.77 | ADAM17 (0.61) | MMP2MMP3MMP1MMP8MMP13 | |
| SCHEMBL6986120 | 0.76 | ADAM17 (0.48) | MMP2MMP3MMP1MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |