Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.45 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.45 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377187 | 0.82 | ATR (0.36) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5377824 | 0.82 | KMT2A (0.41) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9904464 | 0.79 | HCAR3 (0.43) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL17801039 | 0.79 | HCAR3 (0.43) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL29444527 | 0.79 | HCAR3 (0.43) | MEN1KMT2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL30040921 | 0.79 | L3MBTL1 (0.44) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL10324481 | 0.79 | L3MBTL1 (0.44) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL23535805 | 0.78 | CNR1 (0.45) | GAAHSD17B10HCAR3RXRARXRB | |
| Lithium SCHEMBL30864302 | 0.78 | L3MBTL1 (0.43) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL30040880 | 0.78 | CNR1 (0.45) | GAAHSD17B10HCAR3RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |