Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4079306 | 0.91 | NPC1 (0.41) | HCAR3RXRARXRBRXRGCNR1 | |
| SCHEMBL18548025 | 0.88 | DGAT2 (0.40) | RXRARXRBRXRGCNR1CNR2 | |
| SCHEMBL10324481 | 0.85 | L3MBTL1 (0.44) | HCAR3RXRARXRBRXRGHSD17B10 | |
| SCHEMBL30040921 | 0.85 | L3MBTL1 (0.44) | HCAR3RXRARXRBRXRGHSD17B10 | |
| SCHEMBL29444527 | 0.85 | HCAR3 (0.43) | HCAR3RXRARXRBRXRGHSD17B10 | |
| SCHEMBL9904464 | 0.85 | HCAR3 (0.43) | HCAR3RXRARXRBRXRGHSD17B10 | |
| SCHEMBL5378173 | 0.85 | RAB9A (0.41) | HSD17B10GAAL3MBTL1CNR1CNR2 | |
| SCHEMBL30182911 | 0.85 | MAPT (0.38) | RXRARXRBRXRGGAACNR2 | |
| SCHEMBL23535805 | 0.84 | CNR1 (0.45) | HCAR3RXRARXRBRXRGHSD17B10 | |
| Lithium SCHEMBL30864302 | 0.84 | L3MBTL1 (0.43) | HCAR3RXRARXRBRXRGHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |