Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 18/20 | 0.51 |
| ▸ | F3 | P13726 | 18/20 | 0.51 |
| ▸ | F2 | P00734 | 17/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274871 | 0.83 | KMT2A (0.49) | — | |
| SCHEMBL5848054 | 0.78 | F7 (0.67) | F7F3F2PRSS1F10 | |
| SCHEMBL1274295 | 0.78 | HSD17B10 (0.47) | — | |
| SCHEMBL7023018 | 0.77 | TPSAB1 (0.47) | F7F3F2PRSS1F10 | |
| SCHEMBL6990052 | 0.77 | F7 (0.45) | F7F3F2PRSS1F10 | |
| SCHEMBL5846880 | 0.76 | F7 (0.61) | F7F3F2PRSS1F10 | |
| SCHEMBL7020341 | 0.73 | TPSAB1 (0.51) | F7F3F2PRSS1TPSAB1 | |
| SCHEMBL7030921 | 0.72 | TPSAB1 (0.44) | F7F3F2PRSS1TPSAB1 | |
| SCHEMBL3242830 | 0.70 | F2 (0.66) | F7F3F2PRSS1TPSAB1 | |
| SCHEMBL6992707 | 0.70 | F7 (0.50) | F7F3F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202975-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2000069834-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2000-11-23 | — | — | WO | disclosed |