Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 13/20 | 0.50 |
| ▸ | F3 | P13726 | 13/20 | 0.50 |
| ▸ | F2 | P00734 | 13/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996885 | 0.84 | ALDH1A1 (0.38) | F7F3F2PRSS1PLAU | |
| SCHEMBL7456064 | 0.79 | BRD4 (0.46) | F7F3F2BCHE | |
| SCHEMBL5848054 | 0.75 | F7 (0.67) | F7F3F2PRSS1 | |
| SCHEMBL5847230 | 0.74 | APP (0.45) | ACHEBCHEAPPPDE5APTGDR2 | |
| SCHEMBL7223343 | 0.70 | MAPT (0.45) | F7F3F2APPPTGDR2 | |
| SCHEMBL7453183 | 0.70 | F7 (0.51) | F7F3F2PRSS1 | |
| SCHEMBL3242830 | 0.67 | F2 (0.66) | F7F3F2PRSS1 | |
| SCHEMBL3261238 | 0.66 | F7 (0.49) | F7F3F2 | |
| SCHEMBL23461145 | 0.65 | F2 (0.65) | F7F3F2PRSS1 | |
| SCHEMBL6989545 | 0.63 | GPR84 (0.41) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |