Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000516 | 0.82 | ALDH1A1 (0.42) | HPGDALDH1A1APPMMP2MMP9 | |
| SCHEMBL8931204 | 0.79 | APP (0.46) | HPGDALDH1A1APPMMP2MMP9 | |
| SCHEMBL12479627 | 0.76 | MEN1 (0.52) | HPGDALDH1A1APPMMP2MMP9 | |
| SCHEMBL7002040 | 0.75 | RAB9A (0.46) | HPGDALDH1A1MMP2MMP9MMP8 | |
| Sulfurous Acid SCHEMBL27325826 | 0.74 | APP (0.41) | HPGDALDH1A1APPMMP2MMP9 | |
| SCHEMBL27462009 | 0.71 | MGAM (0.48) | HPGDALDH1A1APPMMP2MMP9 | |
| SCHEMBL7001469 | 0.70 | MEN1 (0.46) | HPGDALDH1A1MMP2MMP9MMP8 | |
| SCHEMBL5752634 | 0.69 | ALDH1A1 (0.53) | HPGDALDH1A1TDP1KDM4EGAA | |
| SCHEMBL3417023 | 0.69 | ALDH1A1 (0.65) | HPGDALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL17111763 | 0.69 | ALDH1A1 (0.49) | HPGDALDH1A1TDP1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1159315-C | 4, 5-pyrrolooxindoles | - | 2004-07-28 | — | — | CN | disclosed |
| EP-1149106-B1 | 4,5-AZOLO-OXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-03-19 | — | — | EP | disclosed |
| CN-1330654-A | 4,5-pyrrolo-oxindoles | HOFFMANN LA ROCHE (DE) | 2002-01-09 | — | — | CN | disclosed |
| EP-1149106-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6197804-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-06 | — | — | US | disclosed |
| US-6153634-A | FOR THERAPY AND PROPHYLAXIS OF CANCER TUMORS; INHIBITOR OFCYCLIN-DEPENDENT KINASES (CDKS) | HOFFMANN-LA ROCHE INC. (US) | 2000-11-28 | — | — | US | disclosed |
| WO-2000035920-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |