Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | C1R | P00736 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | KLK3 | P07288 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002040 | 0.81 | RAB9A (0.46) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL18894336 | 0.74 | MEN1 (0.49) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL7000516 | 0.74 | ALDH1A1 (0.42) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL16901142 | 0.74 | MEN1 (0.60) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL5752634 | 0.71 | ALDH1A1 (0.53) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL18915053 | 0.71 | MEN1 (0.48) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL6990067 | 0.70 | HPGD (0.43) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL3417023 | 0.68 | ALDH1A1 (0.65) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL17111763 | 0.68 | ALDH1A1 (0.49) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL5831917 | 0.68 | MMP2 (0.55) | MEN1KMT2AMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149106-B1 | 4,5-AZOLO-OXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-03-19 | — | — | EP | disclosed |
| EP-1149106-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6197804-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-06 | — | — | US | disclosed |
| US-6153634-A | FOR THERAPY AND PROPHYLAXIS OF CANCER TUMORS; INHIBITOR OFCYCLIN-DEPENDENT KINASES (CDKS) | HOFFMANN-LA ROCHE INC. (US) | 2000-11-28 | — | — | US | disclosed |
| WO-2000035920-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |